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Antiviral activity and cytotoxicity of nelfinavir and its metabolites in acute infection of CEM-SS cells with HIV-1 RFa
| Compound | EC50 (nM) | TC50 (μM) | TI |
|---|---|---|---|
| Nelfinavir | 30.1 | 28.9 | 960 |
| M1 (AG1365) | 150.8 | 26.1 | 173 |
| M8 (AG1402) | 34.2 | 96.6 | 2,825 |
Antiviral efficacy was determined by measuring MTT reduction 6 days after infection. Results represent the mean of two experiments.
