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Antiviral activity and cytotoxicity of nelfinavir and its metabolites in acute infection of MT-2 cells with HIV-1 IIIBa
| Compound | EC50 (nM) | TC50 (μM) | TI |
|---|---|---|---|
| Nelfinavir | 60.2 | 11.1 | 184 |
| M1 (AG1365) | 653.3 | 13.3 | 20 |
| M8 (AG1402) | 85.6 | 92.6 | 1,082 |
Antiviral efficacy was determined by measuring MTT reduction 7 days after infection. Results represent the mean of two experiments.
