Antiviral activity of compounds 5a, b, 3a, g, 6a against influenza virus A/Puerto Rico/8/34 (H1N1) on the MDCK cell linea.
| No. | Compound | CC50, μM | IC50, μM | SI |
|---|---|---|---|---|
| 1 | 5a | >815 | 177 ± 21 | 5 |
| 2 | 5b | 378 ± 26 | 205 ± 19 | 2 |
| 3 | 3a | 789 ± 57 | >314 | 3 |
| 4 | 3g | 263 ± 19 | >91 | 3 |
| 5 | 6a | >877 | 58 ± 8 | 15 |
| 6 | Ribavirin | >2130 | 36 ± 5 | 59 |
a
CC50 – 50% cytotoxic concentration, the concentration resulting in death of 50% of cells in culture; IC50 – 50% inhibiting concentration, the concentration resulting in a 50% decrease of virus production as compared to the control; SI – selectivity index (CC50/IC50).