Table 2.
Paired analysis of pulmonary function tests measurements at 45 and 180 days.
| Variable | n | Ward, mean (±SD) |
p | n | ICU, mean (±SD) |
p-value | ||
|---|---|---|---|---|---|---|---|---|
| D45 | D180 | D45 | D180 | |||||
| BMI | 109 | 31.0 (7.1) | 31.2 (7.2) | 0.294 | 98 | 31.2 (7.0) | 31.9 (6.9) | < 0.0001 |
| VC, liter a | 99 | 3.1 (0.9) | 3.2 (0.9) | < 0.0001 | 84 | 3.0 (0.8) | 3.3 (0.9) | < 0.0001 |
| VC, % of preda | 99 | 88.1 (13.7) | 92.9 (15.1) | < 0.0001 | 84 | 81.3 (17.0) | 89.4 (16.5) | < 0.0001 |
| FVC, litersa | 105 | 2.9 (0.9) | 3.1 (0.9) | < 0.0001 | 94 | 2.9 (0.8) | 3.2 (0.9) | < 0.0001 |
| FVC, % of preda | 105 | 83.7 (13.8) | 88.7 (15.4) | < 0.0001 | 94 | 78.0 (16.0) | 87.1 (19.7) | < 0.0001 |
| FEV1, litersa | 105 | 2.2 (0.7) | 2.3 (0.7) | < 0.0001 | 94 | 2.3 (0.6) | 2.5 (0.7) | < 0.0001 |
| FEV 1,% of preda | 105 | 80.1 (16.5) | 84.6 (18.0) | < 0.0001 | 94 | 77.2 (15.6) | 84.7 (16.5) | < 0.0001 |
| FEV 1/FVC, %a | 105 | 76.3 (10.5) | 75.9 (10.8) | 0.394 | 93 | 79.9 (6.7) | 78.9 (8.5) | 0.212 |
| TLC, litersa | 92 | 4.9 (1.1) | 5.1 (1.2) | 0.001 | 79 | 4.8 (1.3) | 5.2 (1.2) | < 0.0001 |
| TLC, % of preda | 92 | 92.9 (13.3) | 98.4 (16.0) | < 0.0001 | 78 | 84.7 (16.2) | 94.4 (19.6) | < 0.0001 |
| RV, litersa | 92 | 1.8 (0.5) | 1.9 (0.5) | 0.161 | 79 | 1.7 (0.6) | 1.8 (0.5) | 0.089 |
| RV, % preda | 92 | 93.9 (26.5) | 101.5 (44.8) | 0.148 | 78 | 88.6 (27.7) | 94.2 (24.9) | 0.151 |
| RV/TLC, % preda | 92 | 111.0 (32.3) | 111.4 (24.6) | 0.922 | 77 | 110.4 (27.4) | 111.0 (26.2) | 0.849 |
| DLCO, ml, min−1, mmHg−1a | 88 | 23.1 (6.4) | 24.3 (6.7) | 0.028 | 74 | 20.8 (8.2) | 22.9 (6.0) | 0.001 |
| DLCO, % predb | 88 | 110.7 (21.9) | 116.0 (18.2) | 0.004 | 73 | 91.6 (26.0) | 103.9 (21.4) | < 0.0001 |
| MIP, cmH2Ob | 91 | 75.9 (31.3) | 76.8 (29.2) | 0.655 | 88 | 77.2 (26.0) | 76.1 (27.8) | 0.595 |
| MEP, % predb | 91 | 85.6 (31.7) | 87.2 (31.5) | 0.533 | 87 | 84.3 (30.8) | 84.5 (32.8) | 0.937 |
| MEP, cmH2Ob | 91 | 91.0 (37.5) | 86.4 (35.8) | 0.139 | 87 | 91.5 (31.2) | 87.6 (30.3) | 0.186 |
| MEP, % pred | 91 | 53.2 (19.1) | 50.8 (18.3) | 0.181 | 86 | 52.8 (18.6) | 50.8 (16.9) | 0.259 |
| 6MWD,ma | 102 | 445.1 (100.6) | 462.0 (111.6) | 0.048 | 92 | 440.3 (99.8) | 466.6 (83.6) | 0.001 |
| 6MWD % preda | 101 | 86.2 (16.7) | 90.3 (18.8) | 0.025 | 92 | 84.5 (20.0) | 90.0 (16.3) | 0.001 |
| HRR1,bpma | 102 | 96.5 (15.7) | 94.0 (16.5) | 0.074 | 90 | 94.8 (17.5) | 89.2 (16.1) | 0.002 |
| ΔHRFinalHRR1, bpma | 102 | 15.8 (13.8) | 20.4 (15.7) | 0.015 | 90 | 17.7 (16.6) | 21.1 (10.9) | 0.109 |
| % HRmaxa | 100 | 70.8 (12.6) | 72.3 (13.2) | 0.298 | 92 | 69.9 (11.7) | 68.1 (10.4) | 0.109 |
a
Missing data (≤ 10%);
b
Missing data (11-12%);
ICU: intensive care unit; SD: standard deviation; BMI: body mass index; VC: vital capacity; FVC: forced vital capacity; FEV1: forced expiratory volume in the first second; TLC: total lung capacity; RV: residual volume; DLCO: carbon monoxide diffusion; MIP: maximal inspiratory pressure; MEP: maximal expiratory pressure; 6MWD,m: six minute walk distance, meters; HRR1: recovery heart rate in the first minute; bpm: beats per minute; Δ: variation; HR: heart rate; % HRmax: percentage of maximum heart rate achieved.