ADMET profile of selected favipiravir derivatives^a (ref. ⁷²).

Comp.	MW	log P	DH/AH	log S	Intestinal absorption (%)	CNS	Tox. (LD50)
1-F	157.10	-0.99	2/3	−1.45	86.80	−3.06	1.92
1-Cl	173.56	−0.48	2/3	−1.94	87.00	−3.07	2.12
1-Br	218.01	−0.37	2/3	−2.03	86.95	−3.06	2.13
2-F	157.10	−0.58	2/4	−1.88	86.04	−3.12	1.52
2-Cl	173.56	−0.06	2/4	−2.29	86.59	−3.11	1.8
2-Br	218.01	0.04	2/4	−2.36	86.53	−3.11	1.81

^aComp = compounds favipiravir derivatives. ADME parameters: MW = molecular weight, DH = number of H bonds donors, AB = number of H bonds acceptors, log P = partition coefficient, log S = predicted aqueous solubility, CNS = predicted central nervous system, Tox = oral rat acute toxicity (mol kg⁻¹).