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. 2022 Mar 15;25(4):103964. doi: 10.1016/j.isci.2022.103964

Figure 2.

Figure 2

Less tissue phospho-tau in DEC2-P384R;PS19 and Npsr1-Y206H;PS19

(A–C) Quantification of Western blot analysis for total tau (A), phospho-tau by AT8 (B), and phospho-tau by AT270 (C) in the hippocampus of three-month-old DEC2-WT;PS19 and DEC2-P384R;PS19 mice. n = 4 mice per group.

(D–F) Quantification of Western blot analysis for total tau (D), phospho-tau (E), and phospho-tau/total tau ratio (F) in the hippocampus of six-month-old DEC2-WT;PS19 and DEC2-P384R;PS19 mice. n = 10 mice per group.

(G–I) Quantification of Western blot analysis for total tau (G), phospho-tau by AT8 (H), and phospho-tau by AT270 (I) in the hippocampus of three-month-old PS19 and Npsr1+/m;PS19 mice. PS19, n = 6; Npsr1+/m;PS19, n = 7.

(J–L) Quantification of Western blot analysis for total tau (J), phospho-tau (K), and phospho-tau/total tau ratio (L) in the hippocampus of six-month-old PS19 and Npsr1+/m;PS19 mice. PS19, n = 10; Npsr1+/m;PS19, n = 9. Student’s two-tailed unpaired t-test was used for analysis.

Data expressed as mean ± SEM, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.