Table 2.
Univariable and multivariable logistic regression analysis of baseline biomarkers associated with significant visual acuity improvement at 12-month.
| Variables | Univariable | P value | Multivariable | P value |
|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | |||
| Age | 3.429 (0.827–14.209) | 0.089 | 1.746 (0.139–21.873 | 0.666 |
| Axial length (mm) | 0.775 (0.424–1.419) | 0.409 | ||
| Spherical equivalent (D) | 0.999 (0.728–1.371) | 0.994 | ||
| BCVA baseline | 0.989 (0.955–1.023) | 0.521 | ||
| Structural OCT biomarkers | ||||
| Subfoveal choroidal thickness (μm) | 1.053 (1.012–1.096) | 0.012* | 1.076 (1.010–1.146) | 0.023* |
| Central fovea thickness (μm) | 1.006 (0.998–1.014) | 0.141 | ||
| Ellipsoid zone integrity, (%) | 4.643 (1.057–20.385) | 0.042* | 21.078 (1.092–406.842) | 0.044* |
| ELM integrity, (%) | 3.361 (0.823–13.722) | 0.091 | 1.953 (0.258–14.777) | 0.517 |
| Subretinal fluid, (%) | 1.607 (0.233–11.092) | 0.630 | ||
| OCTA biomarkers | ||||
| Morphology | ||||
| Medusa or sea-fan/tangled, (%) | 1.773 (0.396–7.932) | 0.454 | ||
| Qualitative biomarkers | ||||
| Branching vessels, (%) | 1.630 (0.411–6.459) | 0.487 | ||
| Anastomotic loops, (%) | 0.779 (0.195–3.118) | 0.724 | ||
| Dark halo, (%) | 2.062 (0.520–8.175) | 0.303 | ||
| Quantitative biomarkers | ||||
| CNV size (mm2) | 0.974 (0.945–1.004) | 0.090 | 1.013 (0.962–1.065) | 0.629 |
| Vessel density (%) | 0.979 (0.917–1.044) | 0.513 | ||
| Vessel length density (%) | 0.987 (0.888–1.096) | 0.804 | ||
| Vessel diameter | 1.054 (0.446–2.493) | 0.905 | ||
| Vessel tortuosity | 1.176 (0.001–1.252) | 0.973 | ||
| Fractal dimension | 0.915 (0.842–0.994) | 0.036* | 0.934 (0.833–1.046) | 0.236 |
| Lacunarity | 0.953 (0.864–1.051) | 0.334 | ||
| No. of anti-VEGF treatments | 0.849 (0.553–1.351) | 0.490 | ||
anti-VEGF: anti- anti-vascular endothelial growth factor; BCVA: best corrected visual acuity; CI: confidence interval; CNV: choroidal neovascularization; ELM: external limiting membrane; D: diopters; No.: numbers; OCT: optical coherence tomography; OCTA: OCT angiography; OR: odds ratio.
*Statistically significant (P < 0.05).