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. 2022 Apr 26;7:49. doi: 10.1038/s41541-022-00461-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Serum neutralizing titers from hamsters vaccinated with TE buffer (control), pIDV-V1, pIDV-V5 were analysed against the SB3 (B1) isolate 4 weeks after receiving the second vaccination and prior to challenge. Titers were also evaluated at 4 and 8 dpi against b Alpha (B.1.1.7) variant and c Beta (B.1.351) as well as d SB3 (B1). Four hamsters were used per group. Two-way ANOVA with repeated measures was used for analysis, and stars denote p < 0.0001.