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. 2022 Apr 26;13:2255. doi: 10.1038/s41467-022-29873-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — C57BL/6 mice infected with the WT M. tuberculosis parent strain (ML2710), the Δrv0455c mutant (ML2711), and the complemented strain (ML2701). Colony-forming unit (CFU) counts in the lungs (a) and spleens (b) of mice infected with the indicated strains. Data represent the mean ± s.d. of four mice per time point. Note that one mouse infected with Δrv0455c mutant was euthanized on day 51 due to an unrelated illness. Source data are provided in the Source Data file. c Gross pathology scans of left lung lobes of mice harvested on day 70 after infection. d Histopathology of lungs of mice harvested on day 70 after infection. The scale bar is 1 mm. Data were obtained from two independent experiments and representative images are shown.