Table 5.
Some Examples of Drug Delivery Systems Based on MSNs
| Drug Delivery Systems Based on Silica | Silica Source | Kind of SNs | Model Drug | Disease | Year of Publication | Ref. |
|---|---|---|---|---|---|---|
| A pH-responsive biogenic MSNs | Rice and wheat hsk | MSN | Dox | Breast cancer | 2021 | [15] |
| A dual pH and temperature-responsive drug delivery system | Rice husk | MSN | Dox | Breast cancer | 2021 | [155] |
| Polydopamine doped MSN-coated reduced graphene oxide for chemo-photothermal therapy | TEOS | MSN | Dox | Cancer | 2019 | [156] |
| Synthesis of MSN–PEI–PEG | TEOS | MCM-41 | Epirubicin hydrochloride | Cancer | 2015 | [157] |
| HER2 aptamer-conjugated, pH-activated MSNs | TEOS | MSN | Dox | Breast cancer | 2019 | [140] |
| Two ligands attached to MSN through a pH-responsive hydrazone linkage | TEOS | MSN | Ruthenium | Cancer | 2021 | [158] |
| A pH-sensitive Carrier based on MSN with bilayer coating of poly (acrylic acid-co-itaconic acid) | TEOS | MCM-41 | Gemcitabine | Cancer | 2016 | [159] |
| Actively targeting breast cancer cells by chitosan-coated/ aptamer conjugated mesoporous silica nanoparticle | TEOS | MSN | DOX | Breast Cancer | 2022 | [160] |
| Chitosan-modified MSNs by three different methods to amine modification of MSNs surface | TEOS | MSN | Methotroxate (MTX) | Cancer | 2021 | [161] |
| Chitosan based supramolecular polypseudorotaxane as a pH-responsive polymer and their hybridization with mesoporous silica-coated magnetic graphene oxide | TEOS | MSN | DOX | Cancer | 2015 | [162] |
| Trastuzumab-conjugated amine modified MSNs by EDC/NHS cross linker (targeted based on HER2-Antibody) | - | MSN | Dox, Trastuzumab | Dual drug delivery and imaging for breast cancer treatment | 2021 | [163] |
| Determine the feasibility of loading rifampin into MSNs | TEOS | MCM41- | Rifampin | Anti- tuberculosis drug. | 2015 | [164] |
| Bionanocomposites based on MSN and alginate for enhanced drug delivery with reduced burst effect and improved mechanical properties | TEOS | SBA-15 and SBA-16 | Prednisolone | Asthma | 2018 | [165] |
| Redox- and enzyme-responsive fluorescent porous silica nanocarriers for drug delivery(pSiO2-ss-CDs/HA) | TEOS | Core-shell MSN | DOX | Cancer | 2018 | [166] |
| Self-fluorescent and stimuli-responsive multifunctional mesoporous silica nanoparticles for drug delivery by dual role curcumuin | TEOS | MCM-41 | DOX and curcumin | Cancer | 2018 | [167] |
| MSN and hollow MSN for chemotherapeutic drug delivery by magnetic field | TEOS | MSN and HMSN | DOX | Cancer | 2018 | [168] |
| Amine functionalized MCM-48 for delivery of poorly soluble drugs | TEOS | MCM-48 | Indomethacin | Anti-inflammatory | 2018 | [169] |
| Poly(NIPAM-co-MPS)-grafted multimodal porous silica nanoparticles as reverse thermoresponsive drug delivery system | TEOS | MSN | Ibuprofen | - | 2017 | [170] |
| Triple-stimuli (protease/redox/pH) sensitive ZnO quantum dots-gated fluorescent porous silica nanocarriers for drug delivery | TEOS | MSN | Amoxicillin | - | 2017 | [171] |
| Redox-responsive MSNs with PEG gatekeepers as carriers for controlled drug delivery | TEOS | MSN | DOX | Cancer | 2015 | [172] |