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. 2021 Oct 29;11(55):35028–35045. doi: 10.1039/d1ra05571b

AAFQDs synthesized are compared based on the strategy used for functionalization, average size, and applications.

Amino acid CD/CQD/GQD/GOQD Synthesis/functionalization method Average size Ref.
l-Alanine GQD Two-step (modified Hummers method/amidation) ∼4.5 nm 72
β-Alanine GOQD Two-step (modified Hummers method/acyl chlorination & reflux) 1–11 nm 60
Arginine GQD One-step (hydrothermal) 5.5 nm 87
l-Arginine GQD Electropolymerization 88
Asparagine GQD Two-step (modified Hummers' method/Amidation) 4.1 nm 72
Aspartic acid GQD Electrodeposition 89
l-Aspartic acid GQD One-step (hydrothermal method) 4–9 nm 90
Cysteine GQD Two-step (hydrothermal/Surface condensation) 3.8 nm 75
GQD Two-step (pyrolysis/Amidation) 2.9 nm 77
l-Cysteine CQD Two-step (pyrolysis/Amidation) 7–10 nm 76
Glutamic acid GQD One-step (pyrolysis) 102.5 nm 91
GQD One-step (hydrolysis) 4.5 nm 92
Glycine GQD One-step (green pyrolysis) 3–5 nm 79
GQD Two-step (modified Hummers' method/amidation) 5.3 nm 72
GQD Two-step (pyrolysis/carbamate reaction) 5.9 nm 33
CQD One-step (pyrolysis) 5–10 nm 78
Histidine GQD One-step (thermal pyrolysis) 3.2 nm 98
GQD One-step (pyrolysis) 5–16 μm 99
GQD One-step (microwave) 200 nm 100
GQD One-step (pyrolysis) 3.7 ± 0.18 nm 53
GQD One-step (pyrolysis) 5.2 nm 94
GQD One-step (pyrolysis) 50 nm 101
GQD One-step (pyrolysis) 2.7 nm 97
GQD One-step (hydrothermal) 3.6 nm 96
l-Isoleucine CD Two-steps (thermal oxidation/surface condensation (amidation)) 3–5 nm 52
l-Lysine CQD One-step (carbonization) <10 nm 4
GQD Two-step (modified Hummers' method/surface condensation) 85
Phenylalanine GQD One-step (pyrolysis) 3.1 nm 95
Proline GQD One-step (pyrolysis) 22 nm 93
Tryptophan GQD Two-step (oxidation/cross-linking amidation) 20–30 nm 46
GQD One-step (pyrolysis) 2–10 nm 83
GQD One-step (hydrothermal) 2.7 nm 86
l-Tryptophan CQD Two-step (hydrothermal/direct surface condensation reaction) 5 nm 81
GQD One-step (thermal cracking) 7 nm 84
l-Tyrosine CD One-step (hydrothermal) 3–5 nm 80
Valine GQD One-step (pyrolysis) 3 nm 34