Table 2.
Compounds with antiviral activity which were isolated from antiviral West African Natural Products
| S/N | Natural Product | Constituent Antiviral Compounds | Antiviral Activity | References | |
|---|---|---|---|---|---|
| 1 | H. fuscum |
Dihydropenicillic acid |
Extract IC50 – EV7: 0.3811 µg/ml; EV19: 1.575 µg/ml | [78] | |
| 2 | M. barteri |
Flavonoids: 3,5-dicaffeoylquinic acid, acteoside, kaempferol-7- O-glucoside and bastadin-11 Stilbenes: vedelianin, schweinfurthin G and mappain |
Mappain IC50 – EV7: 1.23 µM; EV19: 0.24 µM Vedelianin IC50 – EV7: 0.025 nM; EV19: 0.0036 nM Schweinfurthin G IC50 – EV7: 0.043 nM; EV19: 0.018 nM |
[54, 84] | |
| 3 | C. aurantifolia | Flavonoids: quercetin, motin, fisetin, naringenin, hesperidin | [64, 67] | ||
| C. paradisi | Flavonoids: quercetin, motin, fisetin, naringenin, hesperidin | [64, 67] | |||
| 4 | L. micranthus | Salidroside (2-(4-hydroxyphenyl) ethyl-β-D-glucopyranoside) | Salidroside IC50—RSV: 10.3 ± 1.50 μg/ml | [83] | |
| 5 | R. farinacea | Sekikaic acid (and other phenolic compounds) |
Ethyl acetate-soluble fraction (ET4) IC50 – HSV-1: 6.09 μg/ml; RSV: 3.65 μg/ml; HIV-1: 0.33 μg/ml; HIV-1 RT 0.022 μg/ml Sekikaic acid IC50 Recombinant RSV: 5.69 µg/ml; RSV A2: 7.73 µg/ml |
[91, 92] |
Table lists antiviral compounds isolated from West African plants following investigations into their antiviral activity
EV7 is Echovirus 7, EV19 is Echovirus 19, HIV is Human Immunodeficiency Virus, HIV RT is Human Immunodeficiency Virus Reverse Transcriptase, HSV is Herpes Simplex Virus, RSV is Respiratory Syncytial Virus