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. 2022 Apr 13;10:868734. doi: 10.3389/fbioe.2022.868734

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Copyright © 2022 Zhu, Tang, Zhu, Chen, Huang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C-BMSC-exo treatment alters HUVEC proliferation and angiogenic activity. (A) Ki67 staining was used to assess HUVEC proliferation in the indicated groups (Scale bar: 50 μm). (B) Representative images of HUVEC tube formation following culture on Matrigel for 12 h in the presence of C-BMSC-exo or BMSC-exo treatments. (C) Numbers of Ki67-positive cells were quantified (n = 3, biological replicates). (D) Numbers of tubes per field of view were quantified, indicating that C-BMSC-exo treatment enhanced tube formation (Scale bar:200 μm) (n = 3, biological replicates). Samples were analyzed in triplicate. *p < 0.05, **p < 0.01.