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. 2022 Apr 13;9:863238. doi: 10.3389/fcvm.2022.863238

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Copyright © 2022 Varzideh, Kansakar, Donkor, Wilson, Jankauskas, Mone, Wang, Lombardi and Santulli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of miRNA-based drug development. Adenovirus, adeno-associated virus (AAV), lentivirus particles, and liposomes are used to deliver miRNA mimics or antimiRs; miRNAs are investigated in vitro, in vivo, and ex vivo models to develop next-generation therapeutics for cardiovascular diseases. CMs, cardiomyocytes; EHTs, engineered heart tissues; hiPSCs, human induced pluripotent stem cells; I/R, ischemia-reperfusion; MI, myocardial infarction; TAC, transverse aortic constriction.