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. 2022 Jan 28;13(5):1510–1529. doi: 10.1016/j.jcmgh.2022.01.014

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Increased inflammation and fibrosis in OGT-KO mice after completion of LR.A, qPCR analysis of pro-inflammatory markers (Tnfa, Il6, Il1b, Ifng), anti-inflammatory marker (Il10) and Kupffer cell marker F4/80 (Adgre1). B, Representative immunofluorescence images (400×) of F4/80 staining, DAPI and merged images of liver sections in OGT-KO mice 28 days after PHX. C, qPCR analysis of markers of stellate cell activation Des, Acta2, Tgfb, Col1a1 and Col1a2 of livers from OGT-KO mice 28 days after PHX. D, Photomicrographs (200×) of picrosirius red stained liver sections showing significant fibrosis. E, Hydroxyproline assay of liver tissue from OGT-KO mice 28 days after PHX. qPCR was normalized to 18S and the median of the control group. Bars represents the mean ± standard deviation. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; and ∗∗∗∗P < .0001.