Figure 7.

Single-cell data comparison with bulk data and between dCCA and iCCA.A and B, Overlapping with a 174-gene classifier from bulk data by either single epithelial cell data (A) or all single-cell data (B). C, UMAP embedding of 12 cell subtypes of all malignant cells either from iCCA or dCCA. D, Volcano plot indicating the DEGs between iCCA and dCCA malignant cells. Red represents upregulated genes in iCCA, whereas blue indicates upregulated genes in dCCA. |Log2FC| ≥ 1; P-value < .05. E, Differences in pathway activity (scored per cell by Gene Set Enrichment Analysis) between iCCA and dCCA.