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. 2022 Feb 24;13(5):1592–1609.e9. doi: 10.1016/j.jcmgh.2022.02.014

Supplementary Table 2.

eCCA Classifier Containing 174 Genes

Gene Cluster
ORM1 Metabolic
FGA Metabolic
ALB Metabolic
HP Metabolic
APOA2 Metabolic
AGT Metabolic
ITIH3 Metabolic
ITIH2 Metabolic
SERPINA6 Metabolic
ITIH4 Metabolic
FGG Metabolic
PCK1 Metabolic
VTN Metabolic
SLC25A47 Metabolic
FGB Metabolic
AZGP1 Metabolic
SERPINA1 Metabolic
SERPINC1 Metabolic
SLC13A5 Metabolic
ITIH1 Metabolic
KNG1 Metabolic
CYP27A1 Metabolic
MGST1 Metabolic
CYP2B6 Metabolic
PBLD Metabolic
APOC2 Metabolic
APOC3 Metabolic
AHSG Metabolic
C9 Metabolic
ALDH4A1 Metabolic
CFB Metabolic
APOB Metabolic
ADH1B Metabolic
TF Metabolic
CYP3A4 Metabolic
APOA1 Metabolic
CYP2E1 Metabolic
VNN1 Metabolic
SEPP1 Metabolic
SERPINA3 Metabolic
APCS Metabolic
EPHX1 Metabolic
CBS Metabolic
RBP4 Metabolic
UGT2B4 Metabolic
CP Metabolic
CYP1A2 Metabolic
CPS1 Metabolic
TTC39C Metabolic
CYP3A5 Metabolic
RPL28 Proliferation
RPL37A Proliferation
STAG3L2 Proliferation
WAC Proliferation
CLIC1 Proliferation
RPS3 Proliferation
POM121C Proliferation
PIK3C2A Proliferation
STAG3L3 Proliferation
YWHAB Proliferation
RPL11 Proliferation
EEF2 Proliferation
PTPN2 Proliferation
RPL36A Proliferation
SERP1 Proliferation
EFTUD2 Proliferation
CNOT7 Proliferation
STK25 Proliferation
UXT Proliferation
RPL41 Proliferation
RPS29 Proliferation
TMBIM6 Proliferation
6-Mar Proliferation
HDGF Proliferation
PAPOLA Proliferation
GNB2L1 Proliferation
SYNCRIP Proliferation
ATP5L Proliferation
MRPL42 Proliferation
FAU Proliferation
KHSRP Proliferation
SPINT1 Proliferation
RPL4 Proliferation
RBM17 Proliferation
RPL14 Proliferation
SMARCE1 Proliferation
MORF4L2 Proliferation
MRPS24 Proliferation
UBE2N Proliferation
UBA52 Proliferation
OST4 Proliferation
TAPBP Proliferation
H2AFY Proliferation
RPS15A Proliferation
SLC25A6 Proliferation
UPF3A Proliferation
RPL5 Proliferation
SNW1 Proliferation
TUBB2C Proliferation
MRFAP1 Proliferation
POSTN Mesenchymal
THBS2 Mesenchymal
SYTL4 Mesenchymal
NRP2 Mesenchymal
INHBA Mesenchymal
NEURL Mesenchymal
COL1A1 Mesenchymal
COL12A1 Mesenchymal
OLFML2B Mesenchymal
SPARC Mesenchymal
COL10A1 Mesenchymal
CDH11 Mesenchymal
TAGLN Mesenchymal
BHLHE40 Mesenchymal
ITGA11 Mesenchymal
VCAN Mesenchymal
MYL9 Mesenchymal
CALD1 Mesenchymal
STON1 Mesenchymal
GREM1 Mesenchymal
LGALS1 Mesenchymal
VIM Mesenchymal
TGFBI Mesenchymal
COMP Mesenchymal
HTRA3 Mesenchymal
FAM127A Mesenchymal
COL11A1 Mesenchymal
CCDC80 Mesenchymal
EHD2 Mesenchymal
OSBPL5 Mesenchymal
COL5A1 Mesenchymal
PALLD Mesenchymal
WIPF1 Mesenchymal
IVNS1ABP Mesenchymal
SULF1 Mesenchymal
TIMP2 Mesenchymal
SH3PXD2B Mesenchymal
FSTL1 Mesenchymal
C5AR1 Mesenchymal
COL6A1 Mesenchymal
PTK7 Mesenchymal
PLOD2 Mesenchymal
DNAJB5 Mesenchymal
CDH13 Mesenchymal
CRISPLD2 Mesenchymal
PLK3 Mesenchymal
COL1A2 Mesenchymal
ROR2 Mesenchymal
SERPINE1 Mesenchymal
LSAMP Mesenchymal
IGH Immune
IGHA1 Immune
PIK3IP1 Immune
CORO1A Immune
IGJ Immune
ATP2A3 Immune
ARHGDIB Immune
IGHM Immune
PTGDS Immune
HIST1H2AE Immune
SMAP2 Immune
PAPSS1 Immune
ITGAX Immune
CD4 Immune
IL23A Immune
ARHGAP9 Immune
CCDC69 Immune
HIST1H2BD Immune
CCR7 Immune
CYR61 Immune
NR4A1 Immune
HIST1H4E Immune
TSC22D3 Immune
TCF7 Immune

eCCA, Extrahepatic cholangiocarcinoma.