TABLE 1.

Characteristics of studies on TCM prescriptions in depressed PD.

TCM formulas	Compositions (pharmaceutical name)	Possible pharmacological mechanism in treating DPD	References
YiNao JieYu decoction	Codonopsis pilosula, Rehmannia glutinosa Libosch, Poria cocos, Uncaria rhynchophylla, Atractylodes macrocephala Koidz, Angelica sinensis, Pinelliae ternate, Ligusticum chuanxiong Hort	Increase the levels of 5-HT, NE, and DA in peripheral blood of DPD patients	Zhou et al. (2019)
ChaiHu ShuGan powder	Paeoniae Rubra Radix, Ligusticum Chuanxiong Hort, Bupleurum Chinense DC, Cyperus rotundus L, Citrus aurantium L, Citrus reticulate Blanco, Glycyrrhiza uralensis Fisch	Regulate the hypothalamus-pituitary-adrenal axis	Maimaiti et al. (2012)
ChaiGan JieYou decoction	Bupleurum chinense DC, Citrus aurantium L, Paeoniae Rubra Radix, Glycyrrhiza uralensis Fisch, Triticum aestivum L, Ziziphus jujuba Mill, Polygala tenuifolia Willd, Acorus tatarinowii	Increase of BDNF expression in the hippocampus	Ma et al. (2021)
BuShen HuoXue ShuGan decoction	Pueraria montana var. lobata, Cyathula officinalis Kuan, Salvia miltiorrhiza Bge, Fructus Ligustri Lucidi, Ligusticum chuanxiong Hort, Gastrodia elata Bl, Curcuma rcenyujin Y, H. Chenet C.Ling, Bupleurum chinense DC, Chaenomeles speciose, Cyperus rotundus L, Buthus martensii Karsch, Polygala tenuifolia Willd, Yerbadetajo Herb, Cornus officinalis Sieb Zucc, Anemarrhena asphodeloides Bge, Glycyrrhiza uralensis Fisch	Improve microcirculation and scavenge oxygen free radicals	Qin et al. (2019)
PingChan JieYu decoction	Achyranthes bidentata BI, Citrus reticulate Blanco, Glycyrrhiza uralensis Fisch, Uncaria rhynchophylla, Bupleurum chinense DC, Fallopia multiflora, Ligusticum chuanxiong Hort	Increase the levels of DA, 5-HT and NE in the striatum	Lu et al. (2010)
Xiao Yao powder	Bupleurum chinense DC, Angelica sinensis, Paeoniae Rubra Radix, Atractylodes macrocephala Koidz, Poria cocos, Glycyrrhiza uralensis Fisch, Zingiber officinale Rosc, Mentha haplocalyx Briq	Enhance the activity of neurotransmitters, protect hippocampal neurons	Tan et al. (2012)
ZiYin HuoXue decoction	Cornus officinalis Sieb. et Zucc, Dioscorea opposite Thunb and Rehmannia glutinosa Libosch, Cyathula officinalis Kuan, Ligusticum chuanxiong hort, Poria cocos, Dendranthema morifolium, Fructus lycii, Gastrodia elata Bl, Alisma orientalis, Paeonia suffruticosa Andr, annia glutinosa Libosch, Lycium barbarum L, Taxillus sutchuenensis, Gastrodia elata Bl, Bombyx mori Linnaeus, Curcuma phaeocaulis Valeton, Paeoniae Rubra Radix, Arisaema heterophyllum Blume	—	Zhang et al. (2013)
ZiShen PingChan decoction	Gastrodia Libosch, Lycium barbarum L, Taxillus sutchuenensis, Paeoniae Rubra Radix, Gastrodia elata Bl, Arisaema heterophyllum Blume, Salvia miltiorrhiza Bge, Anemarrhena asphodeloides Bge, Lilium lancifolium Thunb, Buthus martensii Karsch, Scolopendra subspinipes mutilans L. Koch	—	Ye et al. (2014)
JieYu YiHao decoction	Lilium lancifolium Thunb, Paeoniae Rubra Radix, Bupleurum chinense DC, Acorus tatarinowii, Angelica sinensis, Ligusticum chuanxiong hort, Rosa chinensis Jacq, Albizia julibrissin Durazz, Rosa rugosa Thunb, Ziziphus jujuba, Ziziphus jujuba Mill	Increase the levels of DA, 5-HT and NE in the brain	Wang et al. (2017)