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. 2022 Apr 13;13:868229. doi: 10.3389/fimmu.2022.868229

Figure 2.

Figure 2

miRNAs control NF-κB signaling pathway in IBD. miR-15, miR-16, and miR-206 downregulate A2aAR or A3AR expression, further inhibiting NF-κB and the level of IL-8 and IFN-γ in UC. miR-323b-5p and miR-146a target and inhibit the TLR4/MyD88/NF-κB signaling pathway. miR-375 competitively inhibits TLR4 expression, further alleviating the generation of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) and the deterioration of intestinal mucus (i.e., ZO-1 and occluding downregulation). miR-125b and miR-223 inhibit TLR4/MyD88/NF-κB signaling pathway through respectively downregulating TRAF6 and IKKα in IBD.