Table 2.
Summary of specific miRNAs and its target gene involved in IBD model.
| miRNAs | IBD model | Expression | Direction | Target genes | References |
|---|---|---|---|---|---|
| miR-21 | DSS-induced mice | Knockout | − | RhoB | (5) |
| miR-29a | DSS-induced mice | Increase | + | ATG9A | (10) |
| miR-30c miR-130a |
AIEC-infected mice | Increase | + | (6) | |
| miR-31 | DSS or TNBS-induced mice | Decrease | + | IL17RA | (7) |
| Colon tissue isolated from UC | Increase | + | TLSP | (17) | |
| miR-106a miR-106b |
HCT116 cells | Increase | + | ATG16L1 | (34) |
| miR-122a | TNF-α-treated Caco-2 cells | Increase | + | Occludin | (14) |
| miR-122b | TNF-α-treated Caco-2 cells | Increase | − | MLCK, c-Jun | (35) |
| miR-126 | DSS-induced mice | Decrease | − | (9) | |
| miR-155 | TNF-α and LPS-treated IMF isolated from UC | Increase | + | SOCS1 | (3) |
| miR-200b | TGF-β1-induced IEC-6 | Increase | − | ZEB1, SMAD2 | (36) |
| miR-206 | HT-29 cells and DSS-induced mice | Increase | + | A3AR | (24) |
| miR-214-3p | HT-29 cells | Decrease | + | STAT6 | (26) |
| miR-223 | TNBS-induced mice | Increase | + | Claudin-8 | (1) |
| miR-375 | Colon tissue isolated from UC and CD | Decrease | + | TLR4 | (15) |
“+” represents promotion; “−” represents suppression; UC, ulcerative colitis; CD, Crohn’s disease; DSS, dextran sodium sulfate; TNBS, 2,4,6-trinitrobenzene sulfonic acid; IEC, intestinal epithelial cells; TGF-β1, transforming growth factor β1; AIEC, adherent-invasive Escherichia coli.; TNF-α, tumor necrosis factor α; LPS, lipopolysaccharide; IMF, intestinal myofibroblasts; A3AR, A3 adenosine receptor; STAT, signal transducer and activator of transcription.