| R2 = R3 = OH (9) |
>40 |
>40 |
>40 |
>40 |
— |
| R2 = R3 = OBz (9a) |
8.4 |
9.3 |
6.0 |
7.5 |
0.80 |
| R2 = R3 = OAs (9b) |
6.7 |
7.1 |
5.3 |
5.2 |
1.02 |
| R2 = ONB, R3 = OH (9c) |
19.5 |
15.3 |
13.9 |
17.9 |
0.78 |
| R2 = R3 = ONB (9d) |
6.9 |
7.0 |
5.3 |
5.5 |
0.96 |
| R2 = OPFMB, R3 = OH (9e) |
17.2 |
13.2 |
12.7 |
14.1 |
0.90 |
| R2 = OFMTB, R3 = OH (9f) |
14.1 |
9.6 |
11.7 |
10.9 |
1.07 |
| R2 = R3 = OFB (9g) |
8.1 |
6.8 |
5.2 |
7.1 |
0.73 |
| R2 = R3 = OFMCM (9h) |
5.5 |
6.2 |
4.1 |
3.1 |
1.32 |
| R1 = R2 = R3 = OH (105) |
>40 |
>40 |
>40 |
>40 |
— |
| R1 = R2 = OBz, R3 = OH (105a) |
19.3 |
15.3 |
12.8 |
10.2 |
1.25 |
| R1 = OH, R2 = R3 = OBz (105b) |
8.8 |
7.6 |
5.2 |
6.3 |
0.83 |
| R1 = R3 = OH, R2 = OAs (105c) |
15.4 |
13.2 |
11.1 |
15.7 |
0.70 |
| R1 = R3 = OH, R2 = OVr (105d) |
8.0 |
15.3 |
14.9 |
20.1 |
0.74 |
| R1 = R2 = OVr, R3 = OH (105e) |
16.0 |
16.9 |
19.7 |
14.7 |
1.34 |
| R1 = R3 = OVr, R2 = OH (105f) |
15.2 |
16.6 |
18.1 |
12.2 |
1.48 |
| R1 = R2 = OH, R3 = ONB (105g) |
5.8 |
7.2 |
6.4 |
6.4 |
1.00 |
| R1 = OH, R2 = R3 = OMNB (105h) |
5.0 |
5.2 |
5.6 |
5.6 |
1.00 |
| R1 = R3 = OH, R2 = OMFMB (105i) |
6.8 |
7.7 |
8.9 |
6.2 |
1.44 |
| R1 = R3 = OH, R2 = OFMTB (105j) |
17.9 |
14.5 |
15.7 |
13.9 |
1.13 |
| R1 = R3 = OH, R2 = OCn (105k) |
8.4 |
6.5 |
7.0 |
6.4 |
1.09 |
| R1 = R3 = OH, R2 = OTr (105l) |
6.4 |
6.0 |
6.6 |
5.2 |
1.27 |
| Paclitaxel (nM) |
4.8 |
5.9 |
5.8 |
2405.4 |
0.0067 |
