Table 1.

The top 6 Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways of the differentially expressed mRNA targets between control and FDM 6 h.

Category	GO term	Description	Count	Genes
BP	GO:0051239	regulation of multicellular organismal process	8	WNT9A,ACVR2B,BMP2,BMPR1B,ACVR1,PTHLH, ACVR2A,RGMA
	GO:0030154	cell differentiation	8	WNT9A,ACVR2B,BMP2,BMPR1B,ACVR1,PTHLH, ACVR2A,RGMA
	GO:0007165	signal transduction	8	WNT9A,ACVR2B,BMP2,BMPR1B,ACVR1,PTHLH, ACVR2A,RGMA
	GO:0048731	system development	8	WNT9A,ACVR2B,BMP2,BMPR1B,ACVR1,PTHLH, ACVR2A,RGMA
	GO:2000026	regulation of multicellular organismal development	7	WNT9A,BMP2,BMPR1B,ACVR1,PTHLH, ACVR2A,RGMA
	GO:0007166	cell surface receptor signaling pathway	7	WNT9A,ACVR2B,BMP2,BMPR1B,ACVR1,ACVR2A,RGMA
MF	GO:0005488	binding	7	WNT9A,ACVR2B,BMP2,BMPR1B,ACVR1,PTHLH, ACVR2A
	GO:0005515	protein binding	6	WNT9A,BMP2,BMPR1B,ACVR1,PTHLH, ACVR2A
	GO:0038023	signaling receptor activity	5	ACVR2B,BMPR1B,ACVR1,ACVR2A,RGMA
	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	4	ACVR2B,BMPR1B,ACVR1,ACVR2A
	GO:0017002	activin-activated receptor activity	3	ACVR2B,ACVR1,ACVR2A
	GO:0048185	activin binding	3	ACVR2B,ACVR1,ACVR2A
CC	GO:0110165	cellular anatomical entity	8	WNT9A,ACVR2B,BMP2,BMPR1B,ACVR1,PTHLH, ACVR2A,RGMA
	GO:0005886	plasma membrane	5	ACVR2B,BMPR1B,ACVR1,ACVR2A,RGMA
	GO:0031224	intrinsic component of membrane	5	ACVR2B,BMPR1B,ACVR1,ACVR2A,RGMA
	GO:0043235	receptor complex	4	ACVR2B,BMPR1B,ACVR1,ACVR2A
	GO:0005887	integral component of plasma membrane	4	ACVR2B,BMPR1B,ACVR1,ACVR2A
	GO:0048179	activin receptor complex	3	ACVR2B,ACVR1,ACVR2A
KEGG pathways	gga04350	TGF-beta signaling pathway	10	BMPR1A,ACVR2B,BMPR2,BMP2,BMPR1B,ACVR1,RGMB, ACVR2A,CHRD, RGMA
	gga04060	Cytokine-cytokine receptor interaction	7	BMPR1A,ACVR2B,BMPR2,BMP2,BMPR1B,ACVR1,ACVR2A
	gga04080	Neuroactive ligand-receptor interaction	4	PTGFR/F2RL1/PRLL/EDNRB