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. 2001 Apr;45(4):1126–1136. doi: 10.1128/AAC.45.4.1126-1136.2001

TABLE 4.

Susceptibility of E. coli MDR gene deletion strains to toxic compounds

W3110 pump deletion strain Strain no. MDR family MIC (μg/ml)
AMP CAM FLOR CLO PUR ERM METH NOV CPRO NOR NAL RIF FUS SM SUL
W3110 HS414 12.5 6.25 6.25 >32 100 50 >640 100 0.01 0.004 3.125 5 400 1.95 2,000
ΔtolC::Kmr HS151 OMF 6.25 0.78 0.78 1 1.56 1.56 20 0.78 0.0025 0.001 0.39 10 3.125 1.95 2,000
ΔyjcP::Kmr HS154 OMF 12.5 6.25 6.25 >32 25 25 >640 100 0.01 0.004 3.125 5 400 1.95 2,000
ΔyohG::Kmr HS157 OMF 12.5 6.25 3.12 >32 25 50 >640 100 0.01 0.004 3.125 5 400 1.95 2,000
ΔylcB::Kmr HS208 OMF 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.002 6.25 2.5 400 1.95 2,000
ΔyjcP ΔyohG ΔylcB ΔtolC::Kmr HS230 OMF 3.12 0.78 0.78 1 1.56 1.56 20 0.78 0.0025 0.001 0.39 10 3.125 1.95 2,000
ΔacrAB::Kmr HS832 RND 3.12 0.78 0.78 16 1.56 1.56 80 1.56 0.0025 0.004 1.56 2.5 3.125 1.95 2,000
ΔacrEF::Kmr HS212 RND 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 5 400 1.95 2,000
ΔyhiUV::Kmr HS193 RND 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 5 400 1.95 2,000
ΔacrD::Kmr HS215 RND 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 5 400 1.95 2,000
ΔyegMNO::Kmr HS199 RND 12.5 6.25 6.25 >32 100 50 >640 100 0.02 0.004 6.25 5 800 3.9 2,000
ΔacrEF ΔacrAB ΔyhiUV ΔacrD ΔyegMNO::Kmr HS276 RND 1.56 0.78 0.78 2 1.56 1.56 20 0.39 0.0025 0.001 1.56 2.5 3.125 1.95 2,000
ΔemrD::Kmr HS196 MF 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 3.125 2.5 400 1.95 2,000
ΔmdfA::Kmr HS221 MF 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 2.5 400 1.95 2,000
ΔemrD ΔmdfA::Kmr HS235 MF 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 3.125 2.5 400 1.95 2,000
ΔemrAB::Kmr HS833 MF 12.5 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 5 400 1.95 2,000
ΔemrKY::Kmr HS205 MF 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 5 400 1.95 2,000
ΔemrKY HS236 MF 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 5 400 1.95 2,000
ΔemrKY ΔemrAB ΔemrD ΔmdfA::Kmr HS275 MF 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 5 400 1.95 2,000
ΔemrE::Kmr HS218 SMR 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 2.5 400 1.95 2,000
ΔtehAB::Kmr HS202 SMR 12.5 6.25 6.25 >32 100 50 >640 400 0.01 0.004 6.25 10 400 1.95 2,000
ΔemrE ΔtehAB::Kmr HS238 SMR 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 5 400 1.95 2,000
ΔybjYZ::Kmr HS273 ABC 6.25 6.25 6.25 >32 100 50 >640 100 0.01 0.004 6.25 2.5 400 1.95 2,000
MIC (μg/ml)
TET DOC CHO TDOC SDS OXAL PROF CV ACR EBR TPP R6G TPAC CTAB DEQC BENZ DAUN PLUM VIOL CCCP
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 800 1,600 1,280 1,600 200 160 62.5 >80 40 50 26
0.156 200 1,600 400 50 >3,200 6.25 0.78 3.12 3.12 6.25 2.5 1.56 25 25 2 0.625 10 50 1.6
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 50 25 100 400 800 1,280 400 100 160 31.2 >80 40 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 50 25 100 400 800 1,280 400 100 160 31.2 >80 40 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 400 1,600 1,280 1,600 200 160 62.5 >80 80 50 26
0.156 200 1,600 400 50 >3,200 12.5 0.78 3.12 3.12 6.25 2.5 3.125 25 2.5 2 0.625 10 50 1.6
0.156 1,600 >12,800 >12,800 100 >3,200 12.5 0.78 3.12 3.12 6.25 2.5 3.125 2.5 2.5 2 0.625 10 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 400 1,600 1,280 1,600 200 160 62.5 >80 80 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 400 1,600 1,280 1,600 200 160 62.5 >80 80 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 400 1,600 1,280 1,600 200 160 62.5 >80 80 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 800 1,600 1,280 1,600 200 160 62.5 >80 80 50 52
0.156 1,600 6,400 400 100 >3,200 6.25 0.78 3.12 1.56 6.25 2.5 1.56 25 2.5 2 0.625 10 25 26
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 400 1,600 1,280 1,600 200 160 62.5 >80 80 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 200 1,600 1,280 1,600 100 160 15.6 >80 >80 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 200 1,600 1,280 1,600 100 160 15.6 >80 80 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 800 1,600 1,280 1,600 200 160 62.5 >80 40 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 400 1,600 1,280 1,600 200 160 62.5 >80 80 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 400 400 1,600 1,280 1,600 200 160 62.5 >80 80 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 200 200 1,600 1,280 1,600 100 160 15.6 >80 80 50 13
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 50 200 1,600 1,280 1,600 100 160 62.5 >80 80 6.25 13
1.25 >3,200 12,800 >12,800 >12,800 >3,200 100 25 400 800 1,600 1,280 1,600 200 160 62.5 >80 80 100 26
1.25 >3,200 >12,800 >12,800 >12,800 >3,200 100 25 50 200 1,600 1,280 1,600 100 160 62.5 >80 80 6.25 13
1.25 >3,200 >12,800 12,800 >12,800 >3,200 100 25 400 400 1,600 1,280 1,600 200 160 62.5 >80 80 50 13
a

Values in bold differ from the W3110 control strain value by ≥4-fold. 

b

Abbreviations: AMP, ampicillin; CAM, chloramphenicol; FLOR, florfenicol; CLO, clotrimazole; PUR, puromycin; ERM, erythromycin; METH, methotrexate; NOV, novobiocin; CIPRO, ciprofloxacin; NOR, norfloxacin; NAL, nalidixic acid; RIF, rifampin; FUS, fusidic acid; SM, streptomycin; SUL, sulfacetamide; TET, tetracycline; DOC, deoxycholate; CHO, sodium cholate; TDOC, sodium taurodeoxycholate; OXAL, sodium oxalate; PROF, proflavin; CV, crystal violet; ACR, acriflavin; EBR, ethidium bromide; TPP, tetraphenylphosphonium; R6G, rhodamine 6G; TPAC, tetraphenylarsonium chloride; DEQC, dequalinium chloride; BENZ, benzalkonium chloride; DAUN, daunomycin; PLUM, plumbagin; VIOL, methyl viologen.