TABLE 4.

FDA approved nanomedicine applied in ocular diseases.

Product	Formulation	Active Ingredient	Indication	Route of Administration	Date of Production	Ref
Restasis®	Nanoemulsion	Ciclosporin A	Chronic Dry eye	Eye drop	1983	Reimondez-Troitiño et al. (2015)
Visudyne®	Liposome	Verteporfin	AMD	Intravitreal injection	2000	Pooja et al. (2018)
Macugen®	Aptamer–polymer nanoparticle	Pegaptanib sodium	Neovascular (wet) AMD	Intravitreal injection	2004	Pooja et al. (2018)
Retisert	Non-biodegradable implant	Fluocinolone acetonide	Uveitis	Intravitreal implant	2005	Reimondez-Troitiño et al. (2015)
Triesence	Suspension	Triamcinolone acetonide	Macular edema	Intravitreal or periocular injection	2007	Khiev et al. (2021)
Durezol®	Nanoemulsion	Difluprednate	Eye inflammation	Eye drop	2008	Reimondez-Troitiño et al. (2015)
Trivaris	suspension	triamcinolone acetonide	uveitis	intravitreal Injection	2008
Ozurdex	Biodegradable implant	dexamethasone	Uveitis/diabetic macular edema	intravitreal implant	2009	Khiev et al. (2021)
Kenalog	Suspension	Triamcinolone acetonide	Macular edema	Intravitreal Injection	2009
Iluvien	Non-biodegradable implant	Fluocinolone acetonide	Diabetic macular edema	Intravitreal implant	2014