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. 2022 Apr 13;10:891763. doi: 10.3389/fcell.2022.891763

FIGURE 1.

FIGURE 1

Schematic representation of the Ror-family receptors (Ror1/Ror2)-mediated signaling, implicated in the regulation of Wnt5a-induced cell polarity, migration, proliferation, and survival. (A) The Ror-family receptors induce filopodia formation and JNK activation via the interaction with FLNa, leading to the regulation of cell polarity and migration. Wnt5a-Ror signaling can also induce activation of c-Src and Dvl, leading to the activation of JNK. c-Src and GSK3, respectively, phosphorylate the Ror-family receptors on their tyrosine and serine/threonine residues, both of which are required for Wnt5a-induced cell polarity and migration. (B) Wnt5a-Ror signaling can activate PI3K-Akt pathway presumably via CKIε associated with Ror1/Ror2, which in turn promotes cell proliferation and survival. c-Src, activated by Wnt5a-Ror signaling, can also induce activation of Akt, thereby contributing to cell proliferation and survival.