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. 2022 Apr 13;10:891763. doi: 10.3389/fcell.2022.891763

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Copyright © 2022 Endo, Kamizaki and Minami.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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| Possible roles of the Ror-family receptors up-regulated by injury and aging in the tissue repair/regeneration and the age-related diseases. (A) Expression levels of Ror1 and/or Ror2 are increased transiently in somewhat restricted (specific) cells, including stem/progenitor cells and astrocytes, within the damaged tissues following injury, via environmental cues including inflammatory cytokines and growth factors. Up-regulated Ror1/Ror2 in turn contribute to the promotion of tissue repair or regeneration. Aging can mediate decreased expression of the Ror-family receptors in the tissue stem/progenitor cells, resulting in the dysfunction of these tissue stem/progenitor cells in regulating tissue repair or regeneration. (B) Sustained expression of Ror1 and/or Ror2 are induced in various types of cells under chronic inflammation caused by aging, thereby contributing to the development or progression of the age-related diseases, including fibrosis, arteriosclerosis, neurodegenerative diseases, and various cancers.