TABLE 1.
Factors and drugs regulating expression of the Ror-family receptors in cancer cells.
| Types of Cancers | Regulated Genes | Analyzed Samples (Cell line, Clinical Sample etc.) | Regulatory Factors | References |
|---|---|---|---|---|
| Breast cancer | Ror1 | MDA-MB 231 | Induced by activation of glucocorticoid receptor | Obradović et al. (2019) |
| Ror1 | HCC1954 | Induced by YAP1 | Islam et al. (2019) | |
| Ror1 | Hs578T, MDA-MB 231 | Induced by Twist | Cao et al. (2018) | |
| Ror1 | BT549, MDA-MB 231 | Inhibited by miR30a | Wang et al. (2018) | |
| Ror1 | Patient derived xenograft | Induced by treatment with paclitaxel | Zhang et al. (2019) | |
| Ovarian cancer | Ror1 | Patient derived primary cell | Induced by dexamethasone | Karvonen et al. (2020) |
| JHOS2, Ovsaho, Kuramochi | ||||
| Ror2 | Patient sample | Induced along with cisplatin resistance | Veskimäe et al. (2018) | |
| A2780 | ||||
| Ror2 | SKOV3 | Induced by STAT3 | Arabzadeh et al. (2016) | |
| Ror1 | SKOV3, COV434 | Inhibited by miR382 | Tan et al. (2016) | |
| Gastric cancer | Ror1 | MKN45 | Induced by STAT3 | Ikeda et al. (2020) |
| Ror1 | AGS, BGC823 | Inhibited by miR27b-3p | Tao et al. (2015) | |
| Leukemia | Ror1 | Patient sample | Induced by STAT3 | Li et al. (2010) |
| Ror1 | Patient sample | Inhibited by berberine | Mohammadlou et al. (2021) | |
| Ror1 | RCH-ACV | Induced by UHRF1 | Chow et al. (2018) | |
| Lung cancer | Ror1 | H1975, SK-LC-5 | Induced by NKX2-1 | Yamaguchi et al. (2012) |
| Ror1 | H1975, PC9, H441, H1299, H2228, HCC4006 | Decreased by geldanamycin (Inhibitor of HSP90) | Khaledian et al. (2021) | |
| Ror1 | Gefitinib resistant PC9, erlotinib resistant HCC827 | Inhibited by miR30a-5p | Yang et al. (2021) | |
| Ror1 | HCC827 | Induced by STAT3 | Wang et al. (2021) | |
| Pancreatic cancer | Ror1 | Panc1, Mia PaCa1 | Induced by SETD8 | Liu et al. (2021) |
| Ror2 | HPDE, HPDE/KRAS | Induced by conditioned medium obtained from adipocytes | Carbone et al. (2018) | |
| Melanoma | Ror1 | UACC1273 | Inhibited by hypoxia | O'Connell et al. (2013) |
| Ror2 | UACC1273 | Induced by hypoxia | ||
| Head and neck squamous cell carcinoma | Ror2 | UPCI: SCC152 | Induced by E6/E7 | Avincsal et al. (2021) |
| Ror2 | SNU899, TU177 | Inhibited by miR338-3p | Yang et al. (2022) | |
| Renal cancer | Ror2 | 786-0 | Induced by HIF1α and HIF2α | Wright and Rathmell, (2010) |