Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 13;12:889583. doi: 10.3389/fonc.2022.889583

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Shi, Tian, Sun, Qiu and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

circOMA1 upregulated c-Myc expression via sponging miR-1294. (A) The intersection of possible target genes predicted by bioinformatics analysis. (B) The expressions of the potential target genes were assessed in OS cells after transfection with miR-1294 mimic or miR-NC. (C) The binding sites between miR-1294 and c-Myc. (D) Luciferase reporter assay confirmed the relationship between miR-1294 and c-Myc. (E) The expression of c-Myc in OS tissues. (F, G) MiR-1270 mimics decreased c-Myc mRNA and protein levels in OS cells. (H) The correlation between miR-1294 and c-Myc. (I, J) Sh-circOMA1 decreased c-Myc mRNA and protein levels in OS cells. (K) The relationship between circOMA1 and c-Myc. (L, M) The mRNA and protein levels of c-Myc in transfected cells. *P < 0.05, **P < 0.01.