Summary of in vivo studies of wound healing potential of C. procera.

Model	C. procera extract/dose/duration	Negative control	Investigation	Result	References
Guinea pigs	20 mL of 1.0% sterile solution of the latex twice daily for 7 days	Excision wounds	Wounds exhibited marked dryness, no visual sign of inflammation	Significant prohealing property	67
Male albino-Wistar rats	Ethanolic extract of bark (50 mg per wound)	Incision and excision wounds	Extract demonstrated wound healing effect by accelerating wound closure and epithelialization	Excellent dermal wound healing potential	69
Wistar rats	Aqueous extract of C. procera (25 mg and 50 mg kg−1)	Incision and excision wounds	Significant (P < 0.05) increase in breaking strength and percentage wound contractions with decreased epithelization period was observed	Significant wound healing property	70