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. 2022 Apr 13;12:824043. doi: 10.3389/fonc.2022.824043

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Copyright © 2022 Hsu, Peng, Hsu, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ligustilide can increase the expression of γ-H2AX and enhance the occurrence of DNA damage in oral cancer cells. After treating oral cancer cells with ligustilide (100 μM) for 24 h, the cancer cells received a dose of 10 Gy. The cancer cells treated with ligustilide and 10 Gy produced a large amount of γ-H2AX protein after 24 h and its expression even exceeded the control group treated with DMSO and 10 Gy for 48 h. GAPDH is internal control. The blots were representative of three independent experiments. Data were expressed as mean ± SD (n ≥ 3).