Table 1.
Clinical trials, completed or active, using oncolytic viruses as treatment in pediatric solid tumors.
| Family | Name | Phase/Country | Modifications | Target Disease | Route | Identifier/Reference |
|---|---|---|---|---|---|---|
| Adenovirus | Delta-24-RGD/ DNX-2401 |
I/Spain | 24-base pair deletion in the Rb-binding region of the E1A gene, insertion of an integrin-binding motif RGD | DMG | intratumoral |
NCT03178032 (104) |
| VCN-01 | I/Spain | 24-base pair deletion in the Rb-binding region of the E1A gene, insertion of an integrin-binding motif RGD, human hyalurodinase gene insertion | Refractory retinoblastoma | intravitreal | NCT03284268 | |
| Icovir-5 (Celyvir)a |
I/Spain | 24-base pair deletion in the Rb-binding region of the E1A gene, integrin-binding motif RGD insertion, E2F-1 promoter insertion | Metastatic/Refractory solid tumors | intravenously |
NCT01844661 (105) |
|
| Icovir-5 (AloCELYVIR)b | Ib/Spain | DMG/ Medullablastoma |
intravenously | NCT04758533 | ||
| Herpex Simples Virus Type 1 | HSV1716/Seprehvir | I/USA | Gene encoding ICP 34.5 protein (RL1) deletion | Non-CNS solid tumors | Intratumoral /intravenously |
NCT00931931 (106) |
| G207 | I/USA | Deletion of the diploid γ134.5 gene, viral ribonucleotide reductase (UL39) disruption by lacZ insertion | Recurrent/Refractory cerebellar brain tumors | intratumoral | NCT03911388 | |
| G207 | I/USA | Progressive/Recurrent supratentorial brain tumors | intratumoral |
NCT02457845 (107) |
||
| G207 | I/USA | Recurrent/Progressive high-grade gliomas | intratumoral | NCT04482933 | ||
| Vaccina Virus | JX-594 | I/USA | Thymidine kinase gene (TK) disruption, human GM-CSF and β-galactosidase gene insertion | Refractory solid tumors | intratumoral |
NCT01169584 (108) |
| Reovirus | Reolysin | II/USA | Unmodified | Metastatic sarcomas | intravenously | NCT00503295 |
| Reolysin | I/USA and Canada | Relapsed/Refractory Solid Tumors | intravenously |
NCT01240538 (109) |
||
| Picornavirus | Seneca Valley Virus | I/USA | Naturally occurring | Advanced Solid Tumors with Neuroendocrine Features | intravenously |
NCT01048892 (110) |
| Poliovirus/ rhinovirus chimera |
PVSRIPO | Ib/USA | Poliovirus type I containing heterologous internal ribosomal entry site of human rhinovirus type 2 | Recurrent malignant glioma (Grade III or IV) | intratumoral | NCT03043391 |
Updated Jan 2022. aCelyvir, Celyvir system consists on autologous MSCs carrying ICOVIR-5. bAloCELYVIR, AloCELYVIR system consists on allogenic MSCs carrying ICOVIR-5.