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. 2022 Apr 13;13:867716. doi: 10.3389/fimmu.2022.867716

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Copyright © 2022 Hendriks, Schasfoort, Koerselman, Dannenberg, Cornet, Beishuizen, van der Palen, Krabbe, Mulder and Karperien

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epitope mapping of antibody response toward RBD. (A) A peptide library of 24 peptides was created with four-amino-acid overlap between sequential peptides. These peptides are located at exposed moieties of the RBD and concentrated on the receptor-binding motif (RBM). The known binding motifs between the RBM and ACE2 receptor are highlighted in green. (B) Frequency of positive antibody responses toward specific peptides IgM, IgG, and IgA. (C) Heatmap of epitope interaction intensity in responder patients. Patients are clustered based on severity and ordered based on total Ig response versus RBD. Heatmap color coding depicts log10 transformed Ig dRU signal.