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The detail of immunization regimens.
| Vaccine components (μg/dose) | PBS/IN | aP/IN | aP + Al(OH)3/IP | aP + 2’,3’-cGAMP/IN | aP + c-di-GMP/IN |
|---|---|---|---|---|---|
| PT | – | 1.25 | 1.25 | 1.25 | 1.25 |
| FHA | – | 1.25 | 1.25 | 1.25 | 1.25 |
| PRN | – | 0.4 | 0.4 | 0.4 | 0.4 |
| Al(OH)3 | – | – | 37.5 | – | – |
| 2’,3’-cGAMP | – | – | – | 5 | – |
| c-di-GMP | – | – | – | – | 5 |
“IN” and “IP” indicate intranasally and intraperitoneally immunized, respectively.
“PT”, “FHA”, and “PRN” indicate pertussis toxoid, filamentous hemagglutinin, and pertactin.
