Stability studies of E-SLNs loaded hydrogel. (p < 0.05).

Physical appearance
Temperature	Time	Colour change	Phase separation	Grittiness	Drug content%	pH
	0 Day	No	No	No	93.78 ± 2.36	7.61 ± 0.9
25–35 °C	30 Days	No	No	No	93.04 ± 3.41	7.58 ± 0.21
	90 Days	No	No	No	91.56 ± 1.61	7.44 ± 0.13
	180 Days	Yes	No	No	90.74 ± 4.07	7.38 ± 0.6
	0 Day	No	No	No	93.78 ± 2.36	7.61 ± 1
	30 Days	No	No	No	93.1 ± 0.03	7.61 ± 0.64
4 °C	90 Days	No	No	No	92.29 ± 1.23	7.59 ± 0.2
	180 Days	No	No	No	91.41 ± 1.42	7.55 ± 0.17