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. 2022 Apr 13;13:805026. doi: 10.3389/fimmu.2022.805026

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Copyright © 2022 Schnabel, Fletemeyer, Lübke, Marti, Wagner and Alber

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tetanus-specific serum antibodies increased after vaccination. Tetanus toxoid-specific serum antibodies were quantified by ELISA before and after booster vaccination. Serum concentrations of (A) pan-Ig, (B) IgG1, (C) IgG3/5, and (D) IgG4/7 are plotted for each horse and time point. Connecting lines represent medians of n=6 (day 28 n=4). Compared to pre-vaccination (day 0) the concentrations of each isotype were statistically significantly increased (p<0.05, except IgG3/5 on day 28 p=0.08) at all time points after vaccination (not depicted).