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. 2021 Nov 22;11(59):37403–37412. doi: 10.1039/d1ra08258b

The IC50 ± SD (μM) valuesa in various cell lines for the synthesized complexes.

Compound MCF-7 MDA-MD-231 HT-29 HeLa Neuro-2a L929
1 56.6 ± 7.78 28.9 ± 2.47 57.9 ± 4.71 39.2 ± 2.98 79.5 ± 8.44 >100
2 15.6 ± 3.24 5.94 ± 1.98 17.3 ± 2.57 41.2 ± 5.07 81.2 ± 9.28 >100
3 17.9 ± 2.66 9.18 ± 2.25 14.6 ± 3.55 37.6 ± 4.61 87.7 ± 6.93 >100
H2pydco 57.9 ± 5.33 45.7 ± 4.75 58.9 ± 5.01 67.1 ± 5.45 >100 >100
bpy 51.3 ± 4.78 24.9 ± 1.98 67.8 ± 5.54 46.5 ± 4.03 97.3 ± 8.70 >100
Cisplatin 5.94 ± 1.47 24.7 ± 4.71 19.3 ± 3.46 0.45 ± 0.13 103 ± 9.8 0.7 ± 0.2
a

The concentration of the complex required to inhibit cell growth by 50%. The experiments were done in triplicate. Data were expressed as the mean of the triplicate. IC50 > 100 μM is considered to be inactive.