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. 2022 Mar 28;28:435–449. doi: 10.1016/j.omtn.2022.03.025

Figure 1.

Figure 1

TAZ alleviated the inflammatory response in microglia

(A) TAZ mRNA expression in BV2 microglial cells after treatment with LPS for 1, 2, 4, and 8 h. N = 3. (B) Western blot analysis of TAZ protein after exposure to LPS. N = 3. TAZ, total TAZ protein; p-TAZ, phospho-TAZ protein; nc, nuclear. (C and D) TAZ mRNA and protein expression after introduction of the TAZ overexpression plasmid. N = 3. Con, empty pcDNA3.1 vector; TAZ, TAZ overexpression plasmid. (E) Overexpression of TAZ down-regulated mRNA levels for IL-1β, IL-6, and TNF-α under inflammatory conditions. N = 6. (F) Activation of TAZ impeded release of IL-1β, IL-6, and TNF-α. N = 6. ∗p < 0.05 versus control in one-way ANOVA with Tukey’s post hoc test, #p < 0.05 versus LPS treatment in one-way ANOVA with Tukey’s post hoc test.