Fig. 10.

The sequence of the NTD of SARS-CoV-1 (blue letters) and SARS-CoV-2 (black letters) spike from residue 1 to 293 and 306, respectively. Mutations found in each of the major variants (yellow shaded residues), and epitopes for seven antibodies known to target SARS-CoV-2 NTD are provided. Epitopes for antagonist and agonist antibodies are shaded green and blue, respectively. The epitopes were retrieved from several references, including Suryadevara et al. [444], Cerutti et al. [172], and Liu et al. [445]. Comb common combined epitope, NTD N-terminal domain, WT wild-type (WA-1)