. 2001 Apr;45(4):1162–1167. doi: 10.1128/AAC.45.4.1162-1167.2001

TABLE 2.

Comparison of IC₅₀s and IC₉₀s of RWJ-270201, oseltamivir carboxylate, and zanamivir against various influenza neuraminidases

Virus	Type	IC₅₀ (nM)			IC₉₀ (nM)
Virus	Type	RWJ-270201	Oseltamivir carboxylate	Zanamivir	RWJ-270201	Oseltamivir carboxylate	Zanamivir
A/Brazil/11/78	H1N1	0.10^a	0.86^a	0.30^a	0.59^a	9.92^a	2.83^a
A/FM/1/47	H1N1	0.81^b	1.50^b	0.48^b	ND^d	ND	ND
A/NWS/33 (grown in MDCK cells)	H1N1	0.63^b	2.20^b	0.49^b	ND	ND	ND
A/NWS/33	H1N1	0.11^a	0.69^a	0.38^a	0.72^a	9.14^a	3.57^a
A/PR/8/34	H1N1	0.09^b	0.99^b	0.34^b	0.83^a	11.3^a	4.49^a
A/Taiwan/1/86	H1N1	0.37^a	2.24^a	0.80^a	2.30^a ^c	40.9^a	7.23^a ^c
A2/Hong Kong/8/68	H2N2	0.18^a	0.25^a	0.76^a	0.96^a	2.19^a	5.38^a
A/Japan	H2N2	0.17^a	0.21^a ^c	0.99^a	0.96^a	2.27^a	9.77^a
A/Singapore/1/57	H2N2	0.20^b	0.01^b	1.78^b	ND	ND	ND
A/Tokyo/3/67	H2N2	1.39^b	1.45^b	1.38^b	ND	ND	ND
A/Turkey/Mass/76 X A/Beijing/32/92	H6N2	1.08^b	0.84^b	1.07^b	ND	ND	ND
A/Aichi	H3N2	0.14^a	0.23^a ^c	0.68^a	0.84^a	2.04^a	5.02^a
A/Belgium/2/81	H3N2	0.29^a	0.24^a	2.32^a	1.37^a	2.00^a	22.5^a
A/Shangdong/09/93	H3N2	0.83^b	0.56^b	1.19^b	ND	ND	ND
A/Virginia/88	H3N2	0.17^a	0.21^a ^c	1.40^a	0.96^a	2.13^a	12.9^a
B/Harbin/07/94	B	0.60^b	6.39^b	3.26^b	ND	ND	ND
B/Hong Kong/5/72 (grown in MDCK cells)	B	9.78^a	24.3^a	6.29^a	ND	ND	ND
B/Hong Kong/5/72	B	1.53^a	7.70^a	3.31^a	29.7^a	14.0^a	58.9^a
B/Lee/40	B	10.8^b	5.74^b	3.38^b	ND	ND	ND
B/Victoria/70	B	5.38^b	5.00^b	17.0^b	ND	ND	ND
B/Y177	B	0.82^a	8.90^a	1.61^a	19.7^a	15.4^a	18.7^a
B/Y253	B	0.84^a	9.01^a	1.53^a	18.8^a	151.9^a	20.1^a
BY263	B	0.99^a	10.4^a	1.63^a	21.0^a	162.8^a	21.7^a

Average of seven determinations; the highest value is less than three times the lowest value except where indicated.

Average of two determinations; the difference between the two values is less than threefold.

The highest value is less than five times the lowest value.

ND, not determined.