TABLE 5.
Effect of delayed treatment with RWJ-270201 and oseltamivir on influenza A/Turkey/Mass/76 X A/Beijing/32/92(H6N2) virus infections in mice
| Compounda | Beginning of therapy (h) | No. of survivors/total no. treatedb | Mean day to deathc |
|---|---|---|---|
| RWJ-270201 | 24 | 9/10∗∗ | 12.0 ± 0.0 |
| RWJ-270201 | 48 | 0/10 | 8.5 ± 1.11 |
| Oseltamivir | 24 | 10/10∗∗ | |
| Oseltamivir | 48 | 1/10 | 8.4 ± 1.05 |
| Vehicle | 0/8 | 6.1 ± 0.35 | |
| Vehicle uninfected | 5/5 |
a
Dosage of each drug was 10 mg/kg/day BID.
b
∗∗, P < 0.001 versus vehicle.
c
Mean day to death of mice dying prior to day 23.