TABLE 6.
Effects of intranasal treatment with RWJ-270201, oseltamivir carboxylate, and zanamivir on influenza A (H6N2) virus infections in mice
| Compound | Dosage (mg/kg/day QD) | No. of survivors/total no. treatedb | Mean day to deathab |
|---|---|---|---|
| RWJ-270201 | 0.1 | 10/10∗∗ | |
| RWJ-270201 | 0.01 | 10/10∗∗ | |
| Oseltamivir carboxylate | 0.1 | 10/10∗∗ | |
| Oseltamivir carboxylate | 0.01 | 6/10∗∗∗ | 13.5 ± 1.85∗∗ |
| Zanamivir | 0.1 | 10/10∗∗ | |
| Zanamivir | 0.01 | 1/9 | 12.1 ± 0.97∗∗ |
| Vehicle | 0/10 | 7.2 ± 0.25 | |
| Vehicle uninfected | 5/5 |
a
Mean day to death of mice dying prior to day 21.
b
∗∗, P < 0.001 versus vehicle; ∗∗∗, P < 0.05 versus vehicle.