Figure 1.

Toxicities, persistence, and response in patient 1 after administration of universal CAR T cells. (A) The change in maximum temperature (Tmax) and the serum level of C-reactive protein (CRP) were tested in patient 1 before and after universal CAR (UCAR) T-cell infusion and CRP recovery after multicycle of methylprednisolone (red arrow), tocilizumab (light green arrow), and etanercept (purple arrow) administration. (B) The serum levels of cytokines, including interleukin-2 (IL-2), IL-6, IL-8, IL-10, and tumor necrosis factor-α (TNF-α), were tested after UCAR T-cell infusion. (C) Chest X-ray showed the appearance of acute pulmonary edema after UCAR T-cell infusion. (D) Persistence of infused UCAR T cells in patient peripheral blood (PB) before and after cell infusion. The level of UCAR T cells was analyzed using quantitative polymerase chain reaction to detect the CAR gene copy number in genomic DNA obtained from PB of patient 1. (E) The change in B-cell number before and after UCAR T-cell infusion. (F) Skin damage in the right trunk developed after UCAR T-cell infusion. The swelling improved after methylprednisolone treatment.