Figure 1.

Overview of inter-organelle communication pathways. Inter-organelle metabolic crosstalk is coordinated by multiple mechanisms, including i) cross-talk between solute transporters for the translocation of small, polar metabolites between organelles ii) physical membrane contact sites, notably for lipid transport and calcium signaling iii) through localized activation of signaling platforms, such as mTORC1 on the lysosomal limiting membrane, which regulates anabolism versus catabolism in response to local metabolite concentrations.