Figure 2.

Metabolic communication via transport across organelle membranes. Mitochondria are biosynthetic hubs that house several biosynthetic and catabolic pathways. Input and output metabolites of mitochondrial pathways are transported across the mitochondrial inner membrane to the intermembrane space (IMS; permeable to the cytosol) primarily via a host of SLC25-family transporters. Metabolites in the cytosol may arise from import across the plasma membrane, via cytosolic metabolic pathways, or via degradative pathways in other organelles, such as the lysosome or the peroxisome. Amino acid transporters are shown in blue, inorganic ion transporters in green, nucleotide and glutathione transporters in red, carboxylate transporters in purple and grey.