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Protomers adjacent to chain A do not display concerted movements. Trimers were aligned along the trimerization regions of all three protomers (residues 150–195). (a and b) Per-residue Cα RMSDs of chain B (a) and chain C (b). Lines are OFSout/OFSmid (green); OFSmid/OFSin (red); and OFSout/OFSin (blue). Transmembrane domains are labeled and alternatively shaded. L, the disordered loop between domains 3 and 4.
