Figure 1.

Plasma NfL concentrations associate with age, gender, and symptom duration in some phenotype groups

Associations of baseline NfL concentrations with age (A), gender (B), and symptom duration (C) assessed using linear regression models adjusted for age, gender, and symptom duration. β coefficients (β), 95% confidence intervals (CIs), and p values are shown for significant associations, where p < 0.025 is considered significant for controls and presymptomatic mutation carriers and p <0.0167 is considered significant for symptomatic groups. In (B), black horizontal bars represent median NfL concentrations. Gray circles represent 11 bvFTD patients and five CBS patients with unknown mutation status, one bvFTD patient with a likely pathogenic GRN variant and three with a TARDBP mutation, and one CBS patient with an intermediate C9orf72 repeat expansion. NfL in plasma samples was measured in duplicate, and the mean concentration of replicates is shown on the base 10 logarithm scale. See Figures S1A–S1C to view NfL concentrations on the linear scale and also see Table S2. The number of individuals per group (n) is shown in figure panels and in Tables 1 and S1.