. 2022 Apr 19;3(4):100607. doi: 10.1016/j.xcrm.2022.100607

Table 2.

Associations of baseline NfL with indicators of disease severity

	Association between NfL and:
Phenotype group	CDR + NACC- FTLDsb	MoCA	SNQ	NAT	MINT	Phonemic fluency	Category fluency	Digit span forward	Digit span backward	Trails B
All FTD groups	n = 658	n = 593	n = 543	n = 483	n = 563	n = 579	n = 579	n = 582	n = 576	n = 441
β (95% CI)	0.04 (0.03, 0.06)^a	−2.22 (−2.79, −1.65)^a	−0.92 (−1.19, −0.64)^a	−0.88 (−1.15, −0.61)^a	−2.13 (−2.96, −1.30)^a	−4.10 (−4.87, −3.33)^a	−4.00 (−4.94, −3.07)^a	−0.50 (−0.73, −0.27)^a	−0.81 (−1.04, −0.58)^a	15.87 (6.66, 25.09)^a
p value	<0.001^a	<0.001^a	<0.001^a	<0.001^a	<0.001^a	<0.001^a	<0.001^a	<0.001^a	<0.001^a	<0.001^a
bvFTD	n = 289	n = 267	n = 236	n = 215	n = 251	n = 255	n = 252	n = 263	n = 257	n = 179
β (95% CI)	0.06 (0.04, 0.09)^a	−2.33 (−3.10, −1.56)^a	−1.11 (−1.51, -−0.72)^a	−1.05 (−1.43, −0.68)^a	−2.31 (−3.27, −1.35)^a	−5.00 (−6.03, −3.96)^a	−5.37 (−6.64, −4.09)^a	−0.50 (−0.82, −0.18)^a	−0.96 (−1.30, −0.62)^a	18.73 (6.34, 31.13)^a
p value	<0.001^a	<0.001^a	<0.001^a	<0.001^a	<0.001^a	<0.001^a	<0.001^a	0.002^a	<0.001^a	0.003^a
nfvPPA	n = 72	n = 61	n = 57	n = 57	n = 57	n = 54	n = 56	n = 58	n = 58	n = 50
β (95% CI)	0.03 (−0.01, 0.07)	−2.33 (−4.74, 0.07)	−1.05 (−2.21, 0.10)	−0.71 (−1.88, 0.46)	−0.09 (−2.63, 2.45)	−2.30 (−4.88, 0.28)	−1.68 (−5.66, 2.30)	−1.16 (−1.84, −0.48)^a	−0.74 (−1.52, 0.04)	33.22 (−1.91, 68.34)
p value	0.17	0.057	0.074	0.23	0.94	0.079	0.40	0.001^a	0.063	0.063
svPPA	n = 84	n = 80	n = 69	n = 70	n = 67	n = 79	n = 75	n = 71	n = 73	n = 74
β (95% CI)	0.06 (0.01, 0.10)^b	−2.92 (−4.89, −0.95)^a	−1.06 (−2.12, 0.00)	−1.46 (−2.34, −0.57)^a	−4.97 (−7.83, −2.11)^a	−2.83 (−5.66, −0.00)^b	−4.87 (−7.68, −2.05)^a	−0.87 (−1.80, 0.07)	−1.16 (−2.02, −0.29)^b	15.03 (−11.92, 41.98)
p value	0.009^b	0.004^a	0.051	0.002^a	<0.001^a	0.050^b	0.001^a	0.069	0.009^b	0.27
CBS	n = 89	n = 71	n = 76	n = 59	n = 75	n = 76	n = 78	n = 77	n = 76	n = 56
β (95% CI)	0.05 (0.01, 0.09)^b	−1.33 (−2.88, 0.23)	0.04 (−0.48, 0.56)	−0.45 (−1.13, 0.23)	−0.29 (−1.11, 0.53)	−2.46 (−4.57, −0.35)^b	−0.33 (−2.88, 2.22)	−0.03 (−0.76, 0.70)	−0.63 (−1.18, −0.07)^b	5.83 (−20.79, 32.45)
p value	0.024^b	0.094	0.88	0.19	0.49	0.023^b	0.80	0.94	0.027^b	0.66
PSP-RS	n = 124	n = 114^b	n = 105^b	n = 82	n = 113	n = 115	n = 118	n = 113	n = 112	n = 82
β (95% CI)	0.03 (−0.00, 0.06)	−1.58 (−2.93, −0.24)^b	−0.71 (−1.32, −0.10)^b	−0.17 (−0.90, 0.56)	−1.01 (−2.30, 0.28)	−2.89 (−4.79, −1.00)^a	−2.95 (−4.89, −1.00)^a	−0.73 (−1.30, −0.16)^b	−0.71 (−1.20, −0.22)^b	35.81 (12.61, 59.02)^a
p value	0.051	0.022^b	0.024^b	0.64	0.12	0.003^a	0.003^a	0.012^b	0.005^b	0.003^a
MCI	n = 57	n = 57	n = 56	n = 49	n = 56	n = 56	n = 56	n = 57	n = 57	n = 56
β (95% CI)	0.29 (0.01, 0.57)^b	−0.93 (−1.83, −0.03)^b	−0.37 (−0.97, 0.24)	0.03 (−0.45, 0.50)	−0.93 (−2.21, 0.36)	−0.55 (−2.52, 1.42)	−2.06 (−4.53, 0.40)	0.08 (−0.50, 0.66)	−0.06 (−0.68, 0.57)	5.16 (−10.37, 20.70)
p value	0.040^b	0.044^b	0.23	0.91	0.15	0.58	0.10	0.78	0.85	0.51

β values, 95% CIs, and p values result from linear regression models that were adjusted for age, gender, symptom duration, and years of education. β values are interpreted as the change in the mean value of the given disease indicator for each doubling of NfL level. The FTD group includes patients with bvFTD, nfvPPA, svPPA, CBS, or PSP-RS. See also Tables S10–S12.

β, regression coefficient; CI, confidence interval; CDR + NACC-FTLDsb, CDR Dementia Staging Instrument plus behavior and language domains from the National Alzheimer’s Disease Coordinating Center FTLD module sum of boxes; MINT, Multilingual Naming Test; MoCA, Montreal Cognitive Assessment; NAT, Northwestern Anagram Test; SNQ, Social Norms Questionnaire; Trails B, Trail Making Test Part B.

p < 0.005 is considered as statistically significant after correcting for multiple testing.

Nominally significant p < 0.05.