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. 2022 Apr 19;3(4):100604. doi: 10.1016/j.xcrm.2022.100604

Figure 2.

Figure 2

Prostate cancer samples have similar overlapping phenotypic profiles

(A) Heatmap of scaled mean signal of marker expression in 55 Franken clusters; numbers are colored according to metaclusters resulting from hierarchical clustering merging (using Pearson correlation dissimilarities) of Franken clusters. Bar plot below the heatmap corresponds to the number of cells found in each cluster.

(B) UMAP map of 23,200 (400 per patient) cells colored by cellular metacluster as indicated in (A).

(C) UMAP map of 23,200 (400 per patient) cells colored by patient.

(D and E) Boxplots of frequencies of the main cell types across all 58 samples from tumor, ABPT, and RPT. Significant changes were seen between tumor and ABPT in the proportion of granulocytes (two-sided Wilcoxon signed rank paired test, p = 0.008). N = 17.

(E) Boxplots of frequencies of the main cell types in samples from all 58 patients in our cohort stratified by intermediate- and high-grade tumors. Changes in luminal and T cell compartments are significant according to a two-sided Mann-Whitney-Wilcoxon test (p = 0.028 and 0.014, respectively). Intermediate N = 46 and high grade N = 12.