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. 2022 Feb 25;71(5):945–960. doi: 10.2337/db21-0382

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© 2022 by the American Diabetes Association

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Gut microbiota alters host intestinal proteome. A: Schematic representation of the experimental design. B: Body weight gain of mice on chow or HFD with or without antibiotics (Abx) treatment with metronidazole (M) or vancomycin (V) (n = 8 per group). Time 0 is the beginning of the HFD, and the dashed line represents the beginning of Abx treatment. ***P < 0.001. C: Principal component (PC) analysis of intestinal proteomes of mice fed chow, HFD, HFD + vancomycin (Vanc), or HFD + metronidazole (Metr). Each dot represents one mouse sample. D: Heat map shows the top 60 proteins affected by Abx and diet. E: Heat map shows the top functional classes affected by Abx treatment.