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. 2022 Jan 31;71(5):1023–1033. doi: 10.2337/db21-0574

Figure 1.

Figure 1

JQ-1 induces hyperglycemia in vivo. A: Experimental protocol. GTT, glucose tolerance test; ITT, insulin tolerance test; ip, intraperitoneal. B: Body weight changes during JQ-1 treatment (n = 5–6). C: Fasting blood glucose levels (4-h fasting, day 10; n = 5–6). Veh, vehicle. Blood glucose levels (D) and AUC (E) during ipGTT (day 6). Plasma insulin (F) and glucagon (G) levels during ipGTT. H: Hematoxylin and eosin (H&E) and insulin staining of pancreatic sections. Scale bar, 200 and 100 μm. I: Islet size (n = 5–6; >100 islets/mouse). ipITT (day10) (J) and glycerol tolerance test (day 4) (K). Data are expressed as means ± SEM. *P < 0.05, **P < 0.01 vs. vehicle-treated mice (Veh).